Using single-molecule optical and AFM imaging and drive-spectroscopy procedures, we seek out to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate pursuits include things like:
1996, initial mesoscopic cost density waves equipment; and initial electrical measurements on one metallic nanocluster among nanoelectrodes
Back in 1991, Sumio Iijima of the NEC Corporation had reported the synthesis of carbon nanotubes. Band structure calculations suggested that these nanotubes could exhibit metallic band conduction. This would be an important gain around the conducting polymers we experienced explored, which were being, in fact, disordered semiconductors offering merely variable-range hopping conductivity.
Our get the job done was immediately adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 released their conclusions on transistors comprised of single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. Within just only a few months, we ended up capable of evaluate transportation by means of somebody single-walled carbon nanotube. Dependant on minimal-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft College of Know-how with the Lively study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were real quantum wires with very extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Microbiology has only been around for the century, due to the fact we began to analyze micro-organisms more severely. I assumed nanobiology was an correct time period, because all molecular Organic relevant interactions take place at the nanoscale: a protein is a couple of nanometres in dimension, DNA is 2 nm thick.’
All parameters ended up a similar for every panel Within this video clip, apart from the Preliminary placement on the 6hb rod (revealed in blue) over the nanopore. Simulations that terminated early because of translocation of the rod throughout the pore are marked by a grey qualifications.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
‘Yes, I recognize people have been astonished at time. At the conclusion of the nineties, After i was in my forties, I was Professor of Molecular Electronics and I have to confess that it experienced turn into a little bit bored, I didn’t discover Substantially anymore. The field went far more into the applying side, how you might combine nanotubes into Digital circuits.
Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing process
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Cees Dekker is Distinguished University Professor at TU Delft. Skilled like a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes during the nineteen nineties. Considering the fact that 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, particularly SMC motor protein; and (iii) building a dwelling artificial cell from lifeless molecules. Dekker is definitely an elected member in the KNAW and fellow towards the APS and also the IOP.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven ceesdekker.net in gray, the rim from the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.